Which Hyaluronic Acid Injection Is Best for Knee Arthritis? A Guide to Ostenil Plus, Durolane and Sinovial HL64
If you've been diagnosed with knee arthritis, you've probably come across hyaluronic acid (HA) injections as a treatment option.
One of the questions I'm asked most often at Revive Women's Physio & Wellbeing Clinic is:
"Which hyaluronic acid injection is best?"
The answer isn't always straightforward.
Different products have different properties, and the most suitable option depends on your symptoms, activity levels, arthritis severity and treatment goals.
Let's take a closer look.
What Are Hyaluronic Acid Injections?
Hyaluronic acid is a naturally occurring substance found within healthy joints.
It helps lubricate and cushion the joint, allowing smooth movement while absorbing shock.
With osteoarthritis, the amount and quality of hyaluronic acid reduce, meaning the joint becomes less able to protect itself.
Hyaluronic acid injections aim to improve lubrication, reduce pain and help you move more comfortably.
They are often considered when:
✔ Pain is affecting walking or exercise
✔ Physiotherapy alone hasn't provided enough relief
✔ Painkillers are no longer effective
✔ You want to delay knee replacement surgery
Ostenil Plus
Ostenil Plus contains high-quality hyaluronic acid together with mannitol, an antioxidant that helps protect the hyaluronic acid from breaking down too quickly.
Benefits
✔ Excellent lubrication
✔ May provide quicker symptom relief
✔ Mannitol may help prolong the effect
✔ Often associated with fewer post-injection flare reactions
✔ Suitable for mild to moderate knee arthritis
At Revive Physio, Ostenil Plus is often an excellent first choice for many patients looking to improve pain and mobility.
Durolane
Durolane contains a highly stabilised form of hyaluronic acid designed to remain in the joint for longer.
Benefits
✔ Single injection treatment
✔ Long-lasting formulation
✔ Suitable for moderate to more advanced arthritis
Some patients find Durolane takes a little longer before they notice improvement compared with other products.
There is also a slightly higher chance of experiencing a temporary inflammatory flare after the injection, although this usually settles within a few days.
Sinovial HL64
Sinovial HL64 combines two different molecular weights of hyaluronic acid.
This aims to provide both excellent lubrication and support for joint movement.
Benefits
✔ Smooth joint lubrication
✔ Supports shock absorption
✔ May improve mobility and function
✔ Suitable for active patients wanting to remain mobile
Many patients report improvements in pain, walking tolerance and overall confidence with everyday activities.
Which Injection Is Best?
There isn't one injection that's best for everyone.
During your assessment we'll consider:
✔ Your age
✔ Activity levels
✔ Severity of arthritis
✔ Previous treatments
✔ X-ray findings (if available)
✔ Your goals
For example, someone wanting to continue running may have different priorities from someone whose main aim is walking comfortably or avoiding knee replacement surgery.
Is Physiotherapy Still Important?
Absolutely.
While hyaluronic acid can reduce pain and improve joint lubrication, combining it with physiotherapy often provides the best long-term outcomes.
Strengthening the muscles around the knee, improving movement patterns and maintaining mobility all help reduce the load placed on the joint.
That's why every patient at Revive Physio receives advice on exercises and activity alongside their injection.
Frequently Asked Questions
How long do hyaluronic acid injections last?
Many patients experience benefits for between 6 and 12 months, although results vary from person to person.
When will I notice improvement?
Some people notice improvement within a few days, while for others it can take 4–6 weeks to achieve the full benefit.
Can I exercise afterwards?
Light walking is encouraged, but strenuous activity should generally be avoided for the first 48 hours.
Hyaluronic Acid Knee Injections in Mosley Common
At Revive Women's Physio & Wellbeing Clinic, every patient undergoes a detailed assessment before treatment.
We offer:
💜 Ostenil Plus
💜 Durolane
💜 Sinovial HL64
Treatment recommendations are based on your symptoms, lifestyle and goals—not simply choosing the most expensive option.
If you're wondering whether hyaluronic acid injections could help your knee arthritis, I'd be happy to discuss your options.
Book Your Assessment
📍 Revive Women's Physio & Wellbeing Clinic – Mosley Common, Worsley
Helping women move better, feel stronger and thrive.